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Insulin‐Like Growth Factor‐1 and Interleukin 6 Predict Sarcopenia in Very Old Community‐Living Men and Women: The Framingham Heart Study
Author(s) -
Payette Hélène,
Roubenoff Ronenn,
Jacques Paul F.,
Dinarello Charles A.,
Wilson Peter W. F.,
Abad Leslie W.,
Harris Tamara
Publication year - 2003
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1046/j.1532-5415.2003.51407.x
Subject(s) - medicine , sarcopenia , bioelectrical impedance analysis , framingham heart study , confounding , endocrinology , cohort , population , anabolism , framingham risk score , body mass index , environmental health , disease
Objectives: To assess the prognostic role of the inflammatory cytokine, interleukin 6 (IL‐6), and insulin‐like growth factor‐1 (IGF‐1) in predicting 2‐year changes in fat‐free mass (FFM) while controlling for potential confounders. Design: Population‐based cohort, the Framingham Heart Study, examined in 1992–93 and 1994–95. Setting: General community. Participants: Two hundred thirty‐two men and 326 women aged 72 to 92. Measurements: IGF‐1 was measured using radio‐immunoassay and cellular IL‐6 production using non‐cross‐reacting radioimmunoassays. FFM was estimated using population‐specific equations for predicting FFM from bioelectrical impedance analysis developed separately for men and women. Results: Higher IGF‐1 predicted smaller loss of FFM in men than lower IGF‐1 did ( P =.002), after adjusting for age, baseline FFM, fat mass, and 2‐year weight changes, whereas cellular IL‐6 was a significant predictor of sarcopenia in women ( P =.02). Weight change was a strong determinant of change in FFM in both sexes ( P <.0001). Conclusion: Predictors of sarcopenia include body composition characteristics that are common to men and women and sex‐specific metabolic predictors. Sarcopenia appears to reflect a withdrawal of anabolic stimuli, such as growth hormone, in men but an increase in catabolic stimuli, such as cellular IL‐6, in women.