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Use of Artificial Networks in Clinical Trials: A Pilot Study to Predict Responsiveness to Donepezil in Alzheimer's Disease
Author(s) -
Mecocci Patrizia,
Grossi Enzo,
Buscema Massimo,
Intraligi Marco,
Savarè Rita,
Rinaldi Patrizia,
Cherubini Antonio,
Senin Umberto
Publication year - 2002
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1046/j.1532-5415.2002.50516.x
Subject(s) - donepezil , medicine , alzheimer's disease , clinical trial , disease , cholinesterase , linear discriminant analysis , dementia , artificial intelligence , computer science
OBJECTIVES: To evaluate the accuracy of artificial neural networks compared with discriminant analysis in classifying positive and negative response to the cholinesterase inhibitor donepezil in a group of Alzheimer's disease (AD) patients. DESIGN: Convenience sample. SETTING: Patients with mild to moderate AD consecutively admitted to a geriatric day hospital and treated with donepezil 5 mg/day. PARTICIPANTS: Sixty‐one older patients of both sexes with AD. MEASUREMENTS: Accuracy in detecting subjects sensitive (responders) or not (nonresponders) to 3‐month therapy with ANNs. The criterion standard for evaluation of efficacy was the scores of Alzheimer's Disease Assessment Scale—Cognitive portion and Clinician's Interview Based Impression of Change—plus scales. RESULTS: ANNs were more effective in discriminating between responders and nonresponders than other advanced statistical methods, particularly linear discriminant analysis. The total accuracy in predicting the outcome was 92.59%. CONCLUSIONS: ANNs appear to be a useful tool in detecting patient responsiveness to pharmacological treatment in AD.