Premium
Folate Deficiency and Risk of Pneumonia in Older People
Author(s) -
Sato Emi,
Ohrui Takashi,
Matsui Toshifumi,
Arai Hiroyuki,
Sasaki Hidetada
Publication year - 2001
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1046/j.1532-5415.2001.49294.x
Subject(s) - medicine , aspiration pneumonia , pneumonia , swallowing , atrophy , stroke (engine) , pediatrics , intensive care medicine , surgery , mechanical engineering , engineering
gression of dementia. 5 Therefore, the low levels of CSF-A 1–42 in AD are likely to reflect progressive accumulation of A in the brain tissue. 5 Our previous study also demonstrated that CSF-A 1–42 levels in AD patients significantly correlated with cerebral glucose metabolism. 6 These results suggest that the CSF-A 1–42 levels may reflect residual brain function in AD patients. Therefore, our findings suggest that reduction in the serum cholesterol levels by lipid-lowering agents such as statins may lead to an increase in the CSF-A 1–42 levels, which might reflect rescue of brain neurons from A -induced neurotoxicity. Further clinical trials of statins aiming at decreasing the risk of developing AD or delaying the progression of AD need to be conducted in a prospective manner.