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Molecular Genetics of Late‐Onset Alzheimer's Disease
Author(s) -
Kamboh M. Ilyas
Publication year - 2004
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1529-8817.2004.00110.x
Subject(s) - apolipoprotein e , linkage disequilibrium , genetics , allele , biology , disease , age of onset , alzheimer's disease , genetic association , genetic linkage , gene , genotype , haplotype , medicine , single nucleotide polymorphism , pathology
Summary Late‐onset Alzheimer's disease (AD) is a complex and multifactorial disease with the possible involvement of several genes. Apolipoprotein E ( APOE ), especially the APOE * 4 allele, has been established as a strong susceptibility marker that accounts for nearly 30% of the risk in late‐onset AD. However, as the APOE * 4 allele is neither necessary nor sufficient for the development of AD, it emphasizes the involvement of other genetic and/or environmental factors which, alone or in conjunction with APOE * 4 , can modify the risk of AD. Recently, genome‐wide linkage or linkage disequilibrium studies on late‐onset AD have provided informative data for the existence of multiple putative genes for AD on several chromosomes, with the strongest evidence on chromosomes 12, 10, 9 and 6. This paper attempts to review the current progress on the identification of additional genetic loci for late‐onset AD.