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On the Power of Affected Relative Pair Designs for Linkage Studies
Author(s) -
LI Z.,
GASTWIRTH J. L.
Publication year - 2004
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1529-8817.2003.00066.x
Subject(s) - linkage (software) , lambda , mathematics , statistics , inheritance (genetic algorithm) , genetics , biology , physics , gene , optics
Summary Using the recurrence risk ratio (λ), Risch (1990b) indicated that affected pairs of distant relatives are preferable to affected sib‐pairs for linkage analysis when λ is large and the mode of inheritance is additive. By using the optimum test for affected sib‐pairs instead of the test used by Risch (1990b), the range of values of λ for which the affected sib‐pair design has larger or smaller power than other pairs is clarified. Risch's conclusion remains true when λ O > 2.5 , however, sib‐pairs have larger power for lower values. As affected sib‐pairs occur smore frequently than other relative pairs, when ascertainment costs are non‐negligible, they may be the most cost‐effective relative pairs to use.