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Chronic Inflammatory Demyelinating Neuropathy and Axonal Cytoskeleton: Morphometric and Immunocytochemical Data
Author(s) -
Fressinaud C,
Jean I
Publication year - 2003
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1046/j.1529-8027.2003.03016_10.x
Subject(s) - neurofilament , immunocytochemistry , pathology , pathophysiology , medicine , chronic inflammatory demyelinating polyneuropathy , nerve biopsy , nerve fiber , antibody , peripheral neuropathy , immunohistochemistry , anatomy , immunology , endocrinology , diabetes mellitus
We report morphometric and immunocytochemical data obtained from nervous biopsy in 7 patients with chronic inflammatory demyelinating neuropathy (CIDP), compared to 5 controls (without neurological involvement). Fiber loss was present in all cases and reached 50 p. 100 or more in 4 cases. The g myelination ratio was elevated in 3 cases only, indicating demyelination. The number of fibers labelled for the L subunit of neurofilaments was normal in cases with moderate fiber loss and dropped down for densities <3900/mm 2 (4 cases). Labelling with anti‐GAP43 antibody was considerably increased in 3 cases, but did not correlate with fiber density or disease duration. These data confirm the importance of axonal lesions in CIDP and offer the opportunity to discuss their pathophysiological mechanisms.