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EFFECTS OF LISINOPRIL ON STREPTOZOTOCIN‐INDUCED DIABETIC NEUROPATHY IN RATS
Author(s) -
Aggarwal M,
Singh J,
Sood S,
Arora B.
Publication year - 2002
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1046/j.1529-8027.2002.2008_11.x
Subject(s) - lisinopril , streptozotocin , medicine , diabetic neuropathy , diabetes mellitus , nerve conduction velocity , histopathology , endocrinology , sciatic nerve , angiotensin converting enzyme , pathology , blood pressure
Streptozotocin (STZ)‐induced diabetic neuropathy in rats was monitored by measuring the motor nerve conduction velocity (MNCV) and histopathology of the tibial nerve. Pretreatment with lisinopril (2 mg/kg p.o., 5 days prior to STZ and continued for 10 weeks) significantly (p < 0.01) prevented deterioration of MNCV ms compared to STZ‐diabetic animals. Nerve sections from the lisinopril pretreated group revealed less structural damage as compared to STZ‐diabetic rats. However lisinopril had no effect on blood sugar i.e., it did not alter the diabetic state. It is concluded that lisinopril prevents the development of experimental diabetic neuropathy in STZ‐induced diabetic rats.