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Response Characteristics Of Cutaneous Mechanoreceptors In Neuropathic Rats
Author(s) -
Bulka A,
Hao JX,
WiesenfeldHallin Z.
Publication year - 2002
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1046/j.1529-8027.2002.02026_20.x
Subject(s) - neuropathic pain , sciatic nerve , nerve conduction velocity , medicine , dorsum , allodynia , nerve injury , anesthesia , neuroscience , nociception , hyperalgesia , anatomy , receptor , biology
The activity of single myelinated afferents was recorded from dorsal roots L4‐5 in normal Sprague‐Dawley rats and animals that developed mechanical hypersensitivity following ischemic injury to the sciatic nerve. The mechanical response properties and conduction velocity of afferents conducting through the injury site (about 50% of units) were similar to controls. However, the majority of afferents not conducting through the injury site exhibited ongoing activity. The results suggest that mechanical allodynia may be at least partly due to the central integration of activity arising from these two populations of afferents in neuropathic rats.