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Hereditary neuralgic amyotrophy (HNA) is genetically heterogeneous
Author(s) -
Kuhlenbaumer G,
Meuleman J,
De Jonghe P,
Falck B,
Young P,
Hunermund G,
Van Broeckhoven C,
Timmerman V,
Stogbauer F
Publication year - 2002
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1046/j.1529-8027.2002.02011_14.x
Subject(s) - locus (genetics) , genetic heterogeneity , homogeneous , genetics , genetic linkage , brachial plexus , biology , phenotype , anatomy , gene , physics , thermodynamics
Hereditary Neuralgic Amyotrophy (HNA) is an autosomal dominantly inherited recurrent focal neuropathy affecting mainly the brachial plexus. Linkage to markers on chromosome 17q25 was found in 1996 and subsequent reports confirmed linkage of HNA to this locus. Recently a family with a chronic undulating rather than remitting‐relapsing clinical course of HNA was described by a Dutch group. This family did not have linkage to the 17q25 locus. Here we describe for the first time clinically and genetically two families with classic remitting‐relapsing HNA that are not linked to the previously described HNA locus on chromosome 17q25. These results demonstrate that clinically homogeneous classical HNA is genetically heterogeneous.