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Zinc finger proteins in the peripheral nerve of adult normal and Trembler mice
Author(s) -
LabatutCazabat Isabelle,
Garbay Bertrand,
Faveraux Alexandre,
Hilmi Souad,
Vital Claude,
Cassagne Claude,
Petry Klaus G.
Publication year - 2001
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1046/j.1529-8027.2001.01020.x
Subject(s) - zinc finger , sciatic nerve , peripheral nervous system , biology , schwann cell , microbiology and biotechnology , pathology , immunology , anatomy , endocrinology , central nervous system , medicine , biochemistry , gene , transcription factor
By using monoclonal antibodies directed against the conserved zinc binding site of zinc finger proteins, we detected 2 prominent zinc finger proteins in rat peripheral nervous system (PNS) during development, and in adult normal and Trembler mice sciatic nerves. The protein of 55 kDa is abundant in adult normal mice and rats, but is weakly expressed in adult Trembler mice. The 29 kDa protein is expressed in neonatal rats and in the Trembler mouse, but is absent in adult rats and mice. These results suggest that the Schwann cell proliferation stage may be associated with the 29 kDa protein expression, and the 55 kDa protein may be implicated in the PNS myelination process.