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Successful Generation Of Peripheral Neuropathy With Onion‐Bulb Formation In The Macrophage Scavenger Receptor Class A Knockout Mouse Treated With Isoniazid
Author(s) -
Naba I,
Yoshikawa H,
Sakoda S,
Itabe H,
Suzuki H,
Kodama T,
Yanagihara T.
Publication year - 2001
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1046/j.1529-8027.2001.01008-12.x
Subject(s) - isoniazid , peripheral neuropathy , knockout mouse , medicine , scavenger receptor , pharmacology , peripheral , pathology , endocrinology , receptor , cholesterol , tuberculosis , lipoprotein , diabetes mellitus
We previously reported successful generation of many onion‐bulbs (OBs) and formation of oxidized phosphatidylcholine after compression injury to the peripheral nerve of mice deficient of macrophage scavenger receptor class A (MSR‐A). In the present study, we employed chemical injury with isoniazid to the peripheral nerve of the MSR‐A knockout mice to investigate the role of the MSR‐A in toxic neuropathy. Peripheral neuropathy has not previously been generated with isoniazid in mice. In the present study, we also noted little histological change after isoniazid administration not only to control littermates but also to the A/J strain mice known to be slow acetylators. Surprisingly, however, we were successful in generating peripheral neuropathy with isoniazid in the MSR‐A knockout mice. Histologically, the predominant feature was the presence of many thinly myelinated fibers with some OBs, which have not been observed in rats with isoniazid neuropathy. Deficiency of the MSR‐A appears to have played an important role in generation of peripheral neuropathy with isoniazid in mice.