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Abnormal Schwann Cell‐Axon Interaction In EBF‐2 “Knock Out” Mice
Author(s) -
Previtali SC,
Corradi A,
Croci L,
Zai F,
Broccoli V,
Consalez GG,
Quattrini A.
Publication year - 2001
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1046/j.1529-8027.2001.01007-44.x
Subject(s) - schwann cell , axon , myelin , biology , microbiology and biotechnology , neuroscience , peripheral nervous system , cell , central nervous system , genetics
Ebf‐2 belongs to the Ebf gene family which has been implicated in various aspects of neural development. In the peripheral nervous system, Ebf‐2 is highly expressed in immature Schwann cells. Ebf‐2 expression is maintained in non myelin‐forming Schwann cells, whereas it is down‐regulated in myelin‐forming Schwann cells. Although its exact role is still unclear, putative target genes include molecules involved in Schwann cell differentiation and maturation such as SCIP, N‐CAM, L1, laminin, and the intermediate filament GFAP. Disruption of Ebf‐2 affects nerve development and results in a defective Schwann cell‐axon interaction. Deficient sorting of large calibre axons that lie in bundles in non‐myelin‐forming Schwann cells, associated in some cases with abnormal myelination, are the main characteristic features. This is likely the result of an aberrant communication between Schwann cells and axons.