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Epidemiology and clinical features of HIV‐1 associated neuropathies
Author(s) -
Verma Ashok
Publication year - 2001
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1046/j.1529-8027.2001.006001008.x
Subject(s) - medicine , peripheral neuropathy , weakness , mononeuritis multiplex , immunology , disease , surgery , diabetes mellitus , vasculitis , endocrinology
Peripheral neuropathy is common in human immunodeficiency virus type‐1 (HIV‐1) infection. Peripheral neuropathies complicate all stages of the HIV‐1 disease and cause considerable morbidity and disability in HIV‐1 infected individuals and acquired immunodeficiency syndrome (AIDS) patients. Whereas symptomatic neuropathies occur in approximately 10% to 15% of HIV‐1‐infected patients overall, pathologic evidence of peripheral nerve involvement is present in virtually all end‐stage AIDS patients. There are 6 major clinical types of HIV‐associated neuropathies that are regularly seen in large HIV‐1 clinics. Distal sensory polyneuropathy (DSP) is the most common among the HIV‐1‐associated neuropathies. DSP generally occurs in later stages of HIV‐1 infection and it follows an indolent and protracted clinical course. The dominant clinical features in DSP include distal pain, paresthesia and numbness in a typical length‐dependent fashion with proximal to distal gradient. Whereas toxic neuropathies—secondary to certain antiretroviral agents—are clinically similar to DSP, their temporal relation to neurotoxic medication helps distinguish them from other HIV‐1‐associated neuropathies. DSP and toxic neuropathy may coexist in a single patient. Acute and chronic inflammatory demyelinating polyradiculoneuropathies (AIDP and CIDP) produce global limb weakness. AIDP may occur at seroconversion and it can therefore be the initial manifestation of HIV‐1 infection. CIDP generally occurs in the mid to late stages of HIV‐1 infection. Progressive polyradiculopathy (PP) occurs in patients with advanced immunodeficiency and is generally caused by the opportunist cytomegalovirus (CMV) infection. Mononeuropathy multiplex (MM) in early stages of HIV‐1 infection is immune mediated, whereas in advanced AIDS it is caused by the CMV infection. Finally, subclinical autonomic nervous system involvement is common in all stages of HIV‐1 infection. Because HIV‐1‐associated neuropathies are diverse in their etiology and pathogenesis, a precise clinical diagnosis is required to formulate a rational therapeutic intervention.