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Acute Inflammatory Responses In Wallerian Degeneration In STZ‐Induced Diabetic Rats
Author(s) -
Kamijo M,
Iwama Y,
Hasegawa K,
Baba M.
Publication year - 2000
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1046/j.1529-8027.2000abstracts-25.x
Subject(s) - wallerian degeneration , medicine , axotomy , diabetes mellitus , streptozotocin , inflammation , endocrinology , pathogenesis , cd8 , sciatic nerve , pathological , pathology , immunology , immune system , central nervous system
Recently, chronic inflammatory cell responses including the upregulation of soluble adhesion molecules have been focused as a pathogenesis of chronic diabetic complications. However the response associated with acute Wallerian degeneration (WD) in diabetic nerve has not been evaluated. In this study, we investigated the pathological profiles of acute inflammation and its role in the development of WD in axotomized sciatic nerves in both control and streptozotocin induced diabetic rats. Activated macrophages were observed in the epineurial and the endoneurial area in both control (C) and diabetes (D) at 3 and 14 days after axotomy. However, the density of macrophages in diabetes was significantly reduced in the endoneurial area (3 days: C 74 ± 8/mm 2 vs. D 28 ± 12/mm 2 , Mean ± SD, P < 0.01). CD8 + lymphocytes were rich in migration on the epineurial area at 3 days after axotomy in control. In contrast, density of CD8 + cell was significantly reduced in diabetes (C 132 ± 19/mm 2 vs. D 75 ± 8/mm 2 , P < 0.005). At 14 days after axotomy, numerous lymphocytes filtrated in the endoneurial area in distal transected stump in control, although the epineurial CD8 + cell accumulation has already diminished. In diabetes, on the other hand, endoneurial lymphocytes were significantly fewer (D 31 ± 8/mm 2 vs. C 82 ± 16/mm 2 , P < 0.001). On the pathological evaluation, a progress of nerve fiber degeneration was suppressed in diabetes. Our results suggested that the inflammatory response during acute WD is reduced in experimental diabetes, which might be a reason for delayed WD in diabetic nerve.