Premium
Cold Exposure Enhances Tactile Allodynia Transiently In Mononeuropathic Rats
Author(s) -
Kauppila T.
Publication year - 2000
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1046/j.1529-8027.2000.absjun.x
Subject(s) - allodynia , reflex , stimulus (psychology) , anesthesia , neuropathic pain , medicine , sciatic nerve , nociception , neuroscience , psychology , hyperalgesia , receptor , psychotherapist
A laser and erythrosin‐B‐induced sciatic nerve injury decreases thresholds of a mechanically induced paw withdrawal reflex and enhances cold‐induced withdrawal behavior of the affected limb. Exposure of the affected paw to a normally innocuous cold stimulus results in a transient decrease in the threshold of the mechanically evoked paw withdrawal reflex in neuropathic but not in intact rats. The present data suggest that in an experimental neuropathic state a normally innocuous cold stimulus may further sensitize spinally mediated withdrawal reflexes to stimuli of another stimulus modality, in this case, to innocuous tactile stimuli. Therefore, testing mechanical allodynia in neuropathic rats immediately after testing cold allodynia may produce artifactual results.