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SUB‐CLINICAL PERIPHERAL NERVE INVOLVEMENT IN PSORIATIC ARTHRITIS
Author(s) -
Di Girolamo C.,
Massini R.,
Lullo F.,
Crisci C.
Publication year - 2000
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1046/j.1529-8027.2000.00513-19.x
Subject(s) - medicine , hypoesthesia , subclinical infection , psoriatic arthritis , psoriasis , peripheral neuropathy , antidromic , peripheral , orthodromic , cutaneous nerve , nerve conduction velocity , sensory nerve , sural nerve , endoneurium , pathology , dermatology , sensory system , peripheral nerve , surgery , anatomy , electrophysiology , neuroscience , endocrinology , biology , diabetes mellitus
Immunological studies document the role of HLA in psoriasis and the correlation between neuropeptides, psoriasis, and related arthritis. Some anecdotal case reports, moreover, describe a noncasual association between peripheral neuropathy and psoriatic manifestations. To verify a possible subclinical peripheral nerve involvement in this disimmune pathology, we started a pilot study in twenty patients with psoriatic arthritis and in whom other common causes of peripheral neuropathies had been ruled out. We performed a complete clinical neurological examination and a neurophysiological examination (orthodromic sensory and motor nerve conduction velocity in median and tibial nerves; antidromic sensory nerve conduction velocity in sural nerve). In 40% of the patients there was a mild but definite “glove‐stocking” hypoesthesia, while hypopallesthesia was detected in only 20%. Electrophysiologic examinations were less informative borderline distal conduction velocities in 30% of patients. These preliminary data suggest a peripheral nerve involvement in this pathology, mainly affecting the small nerve fibres.