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Chronic inflammatory demyelinating polyneuropathy caused by HIV infection in a patient with asymptomatic CMT 1A
Author(s) -
Rajabally Yusuf,
Vital Anne,
Ferrer Xavier,
Vital Claude,
Julien Jean,
Latour Philippe,
Vandenberghe Antoon,
Lagueny Alain
Publication year - 2000
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1046/j.1529-8027.2000.00014.x
Subject(s) - chronic inflammatory demyelinating polyneuropathy , asymptomatic , medicine , disease , immunology , pathology , biopsy , dermatology , antibody
It is well known that patients with Charcot‐Marie‐Tooth (CMT) disease are liable to present with episodes of cortisone‐responsive demyelination, and a superimposed inflammatory component has been suggested. We report a patient who presented with a chronic inflammatory demyelinating polyneuropathy due to a recent HIV infection, which revealed a previously asymptomatic CMT 1A disease documented by identification of the characteristic duplication on the p11.2 region of chromosome 17. The inflammatory process was characterized by pathologic findings on a superficial peroneal nerve biopsy, and the patient improved significantly after corticotherapy. This report gives support to the hypothesis of a genetic susceptibility to inflammatory demyelinating processes in certain CMT kindreds.