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Clues to the Genetic Influences of Drug Responsiveness in Epilepsy
Author(s) -
Ramachandran V.,
Shorvon Simon D.
Publication year - 2003
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1046/j.1528-1157.44.s.1.13.x
Subject(s) - epilepsy , drug , neuroscience , antiepileptic drug , medicine , psychiatry , psychology , bioinformatics , pharmacology , biology
Summary: Despite the introduction of newer antiepileptic drugs (AEDs), nonresponsiveness to AEDs remains a common problem in epilepsy clinics. There may be important genetic determinants for responsiveness, and this discussion focused on some potential areas: drug transporters; drug‐metabolizing enzymes, and ion channels. We review the literature and speculate the contribution of each of these factors in management of patients with epilepsy in the future.