Premium
Myoinositol Abnormalities in Temporal Lobe Epilepsy
Author(s) -
Wellard R. Mark,
Briellmann Regula S.,
Prichard James W.,
Syngeniotis Ari,
Jackson Graeme D.
Publication year - 2003
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1046/j.1528-1157.2003.44102.x
Subject(s) - temporal lobe , epilepsy , hippocampal sclerosis , frontal lobe , nuclear medicine , magnetic resonance imaging , medicine , hippocampus , psychology , neuroscience , radiology
Summary: Purpose: This study used magnetic resonance spectroscopy (MRS) to examine metabolite abnormalities in the temporal and frontal lobe of patients with temporal lobe epilepsy (TLE) of differing severity. Methods: We investigated myoinositol in TLE by using short‐echo MRS in 34 TLE patients [26 late onset (LO‐TLE), eight hippocampal sclerosis (HS‐TLE)], and 16 controls. Single‐voxel short‐echo (35 ms) MR spectra of temporal and frontal lobes were acquired at 1.5 T and analyzed by using LCModel. Results: The temporal lobe ipsilateral to seizure origin in HS‐TLE, but not LO‐TLE, had reduced N ‐acetylaspartate (NA) and elevated myoinositol (MI; HS‐TLE NA, 7.8 ± 1.9 m M , control NA, 9.2 ± 1.3 m M ; p < 0.05 ; HS‐TLE MI, 6.1 ± 1.6 m M , control mI 4.9 ± 0.8 m M , p< 0.05 ). Frontal lobe MI was low in both patient groups (LO‐TLE, 4.3 ± 0.8 m M ; p < 0.05 ; HS‐TLE, 3.6 ±.05 m M ; p < 0.001 ; controls, 4.8 ± 0.5 m M ). Ipsilateral frontal lobes had lower MI (3.8 ± 0.7 m M ; p < 0.01) than contralateral frontal lobes (4.3 ± 0.8 m M ; p < 0.05) . Conclusions: MI changes may distinguish between the seizure focus, where MI is increased, and areas of seizure spread where MI is decreased.