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Amygdala Kindling in Proechimys guyannensis Rat: An Animal Model of Resistance to Epilepsy
Author(s) -
De Amorim Carvalho Reinaldo,
Arida Ricardo Mario,
Cavalheiro Esper A.
Publication year - 2003
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1046/j.1528-1157.2003.32202.x
Subject(s) - kindling , epilepsy , amygdala , rodent , psychology , kindling model , endocrinology , medicine , neuroscience , biology , ecology
Summary: Purpose: This study examined the effect of amygdala kindling development in Proechimys guayannensis rat, a common rodent of the Amazon basin. Methods: Adult male P. guayannensis animals (n = 43) and adult male Wistar rats (n = 14) were submitted to electrical amygdala kindling. Results: From 43 Proechimys rats submitted to the kindling process, only three animals reached stage 5 of kindling. During the kindling development (stages 4–5), these animals had behavioral alterations different from those observed in Wistar rats. A longer time spent in stages 1–3 and 5 and longer afterdischarge duration in stages 1–4 was observed in the Proechimys group compared with the Wistar group. The number of wet‐dog shakes also was reduced in the Proechimys group during the kindling process. Conclusions: These findings suggest natural endogenous inhibitory mechanisms in this animal species.