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Agranulocytosis Associated with Lamotrigine in a Patient with Low‐grade Glioma
Author(s) -
Fadul Camilo E.,
Meyer Louise P.,
Jobst Barbara C.,
Cornell Cornelius J.,
Lewis Lionel D.
Publication year - 2002
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1046/j.1528-1157.2002.31801.x
Subject(s) - lamotrigine , medicine , granulocyte colony stimulating factor , glioma , anticonvulsant , chemotherapy , neutropenia , anesthesia , epilepsy , surgery , pediatrics , psychiatry , cancer research
Summary: Purpose: To report agranulocytosis associated with lamotrigine (LTG) in a patient with a brain tumor. Methods: A 59‐year‐old woman with a low‐grade glioma and difficult‐to‐control partial seizures developed agranulocytosis between 9 and 14 weeks after starting LTG. The patient underwent chemotherapy 2 years previously. Results: After stopping LTG, the agranulocytosis persisted for 9 days despite 7 days of granulocyte–colony‐stimulating factor (G‐CSF), and ultimately resolved. Conclusions: In this case, the use of LTG was associated with the development of agranulocytosis, and it is likely that this association was causative.