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Lack of Association Between an Interleukin 1 Beta (IL‐1β) Gene Variation and Refractory Temporal Lobe Epilepsy
Author(s) -
Buono Russell J.,
Ferraro Thomas N.,
O'Connor Michael J.,
Sperling Michael R.,
Ryan Stephen G.,
Scattergood Theresa,
Mulholland Nicole,
Gilmore Joan,
Lohoff Falk W.,
Berrettini Wade H.
Publication year - 2001
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1046/j.1528-1157.2001.42900.x
Subject(s) - hippocampal sclerosis , temporal lobe , epilepsy , genotype , polymorphism (computer science) , allele , biology , allele frequency , genetics , medicine , gene , neuroscience
Summary: Purpose: We attempted to confirm recent findings of Kanemoto et al. that demonstrated a positive association (p < 0.017) between a polymorphism in the promoter region of the interleukin 1‐β (IL‐1β) gene and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS). Methods: We determined the frequency of this polymorphism in a group of 61 TLE+HS patients of European ancestry and compared it with that found in 119 ethnically matched control subjects. Results: Analysis of genotype and allele frequencies showed no statistically significant difference in the distribution of the polymorphism between the two groups (p = 0.10). Conclusions: These data suggest that this IL‐1β promoter polymorphism does not act as a strong susceptibility factor for TLE+HS in a population of individuals of European ancestry.