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Correlation of Scalp EEG and 1 H‐MRS Metabolic Abnormalities in Temporal Lobe Epilepsy
Author(s) -
Maton B.,
Gilliam F.,
Sawrie S.,
Faught E.,
Hugg J.,
Kuzniecky R.
Publication year - 2001
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1046/j.1528-1157.2001.25999.x
Subject(s) - electroencephalography , ictal , temporal lobe , epilepsy , lateralization of brain function , scalp , psychology , concordance , audiology , medicine , neuroscience , anatomy
Summary: Purpose: To correlate the interictal spike field and region of seizure onset with the distribution of 1 H‐MRS abnormalities in temporal lobe epilepsy (TLE) and improve our understanding of the clinical significance of 1 H‐MRS abnormalities. Methods: Scalp electroencephalogram (EEG) monitoring and proton magnetic resonance spectroscopy ( 1 H‐MRS) results were correlated in 31 consecutive patients with TLE. Results: Lateralized 1 H‐MRS–based hippocampal abnormalities were recorded in 95% of the patients with unilateral interictal spikes, with a high degree of concordance for the lateralization side (90%). In 64% of the patients with normal or bilateral interictal EEG spikes, 1 H‐MRS provided lateralizing information. Bilateral 1 H‐MRS abnormalities, with or without lateralization, were 3 times more frequent than bitemporal EEG spikes. Anterior predominance of the 1 H‐MRS abnormalities was more frequent in patients with anterior temporal EEG spiking (50%), than in patients without this EEG distribution (18%). Similar association was noted between distribution of 1 H‐MRS abnormalities and region of EEG seizure onset. Conclusions: Our results show a moderate level of concordance between the distribution of 1 H‐MRS and EEG abnormalities. 1 H‐MRS identifies abnormalities contralateral to the predominant seizure focus more often than does EEG and may provide lateralizing information in patients with nonlateralizing interictal EEG.