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Hypohidrosis Related to the Administration of Topiramate to Children
Author(s) -
Arcas Joaquín,
Ferrer Teresa,
Roche María C.,
MartínezBermejo Antonio,
LópezMartín Valentín
Publication year - 2001
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1046/j.1528-1157.2001.09201.x
Subject(s) - topiramate , pilocarpine , adverse effect , sweat , medicine , sudomotor , anesthesia , epilepsy , anticonvulsant , side effect (computer science) , iontophoresis , psychiatry , radiology , computer science , programming language
Summary: Purpose: Topiramate (TPM) is an antiepileptic agent, first licensed in the United Kingdom in 1994, that is used in the treatment of patients with refractory seizure disorders. TPM is a monosaccharide d ‐fructose derivate, with sulfamate function, and so far, few adverse side effects have been reported. Methods: We describe three patients with epilepsy who were treated with TPM and developed hypohidrosis, heat and exercise intolerance, as well as fever. The sudomotor function was assessed after peripheral stimulation with pilocarpine iontophoresis. Results: Sweat response was reduced in all three patients. Signs and symptoms ceased after drug suppression. Conclusions: This side effect associated with TPM, which has not been described previously, can be clinically significant during heat stress and exercise challenge.