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Management Strategies for Refractory Localization‐Related Seizures
Author(s) -
Brodie Martin J.
Publication year - 2001
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1046/j.1528-1157.2001.042suppl.3027.x
Subject(s) - lamotrigine , tiagabine , vigabatrin , topiramate , gabapentin , medicine , anticonvulsant , partial seizures , epilepsy , refractory (planetary science) , felbamate , intensive care medicine , pediatrics , psychiatry , alternative medicine , physics , pathology , astrobiology
Summary: Localization‐related epilepsy, the most common type of seizure disorder, often provides major management problems. Five new antiepileptic drugs (AEDs) with different mechanisms of action have been licensed in the United Kingdom in the 1990s for adjunctive use in the management of poorly controlled partial seizures. These were, in chronologic order, vigabatrin, lamotrigine, gabapentin, topiramate, and tiagabine. Their practical deployment is explored here. Mention also is made of clobazam and acetazolamide. Combination therapy with two or even three AEDs having complementary pharmacologic effects can provide an essential contribution to the management of partial seizures. This article discusses some of the pharmacologic strategies used in treating patients with refractory localization‐related epilepsy.