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Stupor from Lamotrigine Toxicity
Author(s) -
Sbei Mouaz,
Campellone Joseph V.
Publication year - 2001
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1046/j.1528-1157.2001.0420081082.x
Subject(s) - lamotrigine , stupor , medicine , valproic acid , toxic encephalopathy , encephalopathy , coma (optics) , toxicity , etiology , anesthesia , pediatrics , psychiatry , epilepsy , physics , optics
Summary: Purpose: To report that acute lamotrigine poisoning may result in severe encephalopathy. Methods: A 55‐year‐old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets. Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy. Results: LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels. Conclusions: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon. LTG toxicity should be considered in patients taking this drug who have depressed mental status.