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Visual Distortion Provoked by a Stimulus in Migraine Associated With Hyperneuronal Activity
Author(s) -
Huang Jie,
Cooper Thomas G.,
Satana Banu,
Kaufman David I.,
Cao Yue
Publication year - 2003
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1046/j.1526-4610.2003.03110.x
Subject(s) - visual cortex , aura , illusion , stimulus (psychology) , migraine with aura , optical illusion , neuroscience , migraine , psychology , photic stimulation , visual perception , audiology , medicine , cognitive psychology , perception , psychiatry
Background.—Migraineurs with visual aura are highly susceptible to illusions and visual distortion and are particularly sensitive to a pattern of regularly spaced parallel lines or stripes. Purpose.—To determine whether the high degree of susceptibility to illusions and visual distortion in migraineurs with aura is associated with hyperneurological activity of the occipital cortex. Methods.—In order to investigate any relationships among neuronal activity, spatial frequency of square‐wave gratings, and self‐described visual distortion, we investigated the neuronal and psychophysical responses to square‐wave gratings in migraineurs with visual aura and in nonheadache controls. Results.—Square‐wave gratings provoked various types of visual distortion and illusions and induced a hyperneuronal response in the visual cortex of migraineurs with visual aura, a response that strongly depended upon the stimulus spatial frequency. Conclusion.—The hyperneuronal activity of the occipital cortex is consistent with general cortical hyperexcitability in migraine.