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A Polymorphism in the Interleukin‐1α Gene Influences the Clinical Features of Migraine
Author(s) -
Rainero Innocenzo,
Pinessi Lorenzo,
Salani Giuliana,
Valfrè Walter,
Rivoiro Chiara,
Savi Lidia,
Gentile Salvatore,
Giudice Rossana Lo,
Grimaldi Luigi M.E.
Publication year - 2002
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1046/j.1526-4610.2002.02103.x
Subject(s) - migraine , aura , genotype , pathophysiology , disease , medicine , migraine with aura , polymorphism (computer science) , interleukin , proinflammatory cytokine , immunology , gene , biology , genetics , cytokine , inflammation
Objective.—To evaluate whether a particular genotype of the interleukin‐1α ( IL1A ) gene affects the clinical features of migraine. Background.—Proinflammatory mediators have been reported to play a role in the pathophysiology of migraine. Recent studies suggest that polymorphisms in the interleukin‐1 genes influence the age at onset and subsequent course of several chronic inflammatory diseases. Methods.—In a group of 269 patients with migraine, we tested the association of the −889 C/T biallelic polymorphism of the IL1A gene with several clinical features of the disease. Results.—Patients with migraine carrying the T/T genotype show an age at onset of the disease that is significantly ( P < .01) lower than IL1A C/C or C/T carriers. In addition, the same genotype was significantly ( P < .05) more frequent in patients with migraine with aura than in patients with migraine without aura. Conclusions.—The results of our study suggest a role for the IL1A gene in modifying the clinical features of migraine.