Premium
Is Blood Homocysteine Elevated in Migraine?
Author(s) -
HeringHanit R.,
Gadoth N.,
Yavetz A.,
Gavendo S.,
Sela B.
Publication year - 2001
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1046/j.1526-4610.2001.01143.x
Subject(s) - migraine , aura , homocysteine , medicine , migraine with aura , stroke (engine) , endocrinology , mechanical engineering , engineering
Objective.—To determine total serum homocysteine levels in a large group of patients with migraine with and without aura. Background.—Hypercoagulable state is a known risk factor for stroke in the young. The existence of a hypercoagulable state has been postulated in migraine and homocysteinemia with young‐onset stroke. To the best of our knowledge, blood homocysteine has not been studied in a significant number of patients with various forms of migraine. Methods.—Total serum homocysteine was measured with high‐performance liquid chromatography in 78 patients with migraine and in 126 age‐ and sex‐matched healthy volunteers. Results.—Seventy‐eight patients aged 18 to 65 years were studied: 22 with migraine with aura and 56 with migraine without aura. Only 1 man had significantly elevated blood homocysteine (38.6 μ mol/L), while another had a borderline elevation (15.8 μ mol/L) (reference value for both sexes in our laboratory is 4 to 14 μ mol/L). Both patients suffered from migraine without aura. Conclusions.—Blood homocysteine is not elevated in migraine.