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Immunological Aspects in Migraine: Increase of IL‐10 Plasma Levels During Attack
Author(s) -
Munno I.,
Marinaro M.,
Bassi A.,
Cassiano M.A.,
Causarano V.,
Centonze V.
Publication year - 2001
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1046/j.1526-4610.2001.01140.x
Subject(s) - migraine , aura , sumatriptan , cytokine , pathogenesis , ictal , plasma levels , medicine , endocrinology , interleukin , immunology , receptor , agonist , epilepsy , psychiatry
In the present study, 23 patients with migraine without aura were monitored during a migraine attack. Plasma levels of interleukin (IL)‐4, IL‐5, IL‐10, and interferon‐ γ were measured by enzyme‐linked immunosorbent assay techniques. Interestingly, we observed low to undetectable IL‐5 and IL‐4 levels, whereas high IL‐10 levels were seen in 52.2% of the patients. Interferon‐ γ plasma levels were undetectable in all patients. After treatment with sumatriptan, 10 patients showed a subsequent decrease in IL‐10 and an increase in both IL‐4 and IL‐5 plasma levels. Although these findings are derived from a limited number of patients, the apparent return to the IL‐4 and IL‐5 cytokine profile observed during the interictal period leads us to speculate that a preferential enhancement of T H 2‐type cytokine production may contribute to the pathogenesis of migraine.