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Predictability of Exogenous Hormone Effect on Subgroups of Migraineurs
Author(s) -
Mueller Loretta
Publication year - 2000
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1046/j.1526-4610.2000.00027.x
Subject(s) - migraine , aura , medicine , menopause , headaches , migraine with aura , pregnancy , hormone replacement therapy (female to male) , triptans , oral contraceptive pill , obstetrics , pediatrics , population , family planning , psychiatry , testosterone (patch) , biology , genetics , environmental health , research methodology
Objective.–To evaluate whether self‐reported past migraine response to reproductive life events (menses, pregnancy, menopause) alters the likelihood of worsening of migraine with exogenous hormone use. Methods.–A retrospective study was conducted on 451 female patients at the University Headache Center who had a diagnosis of migraine with or without aura. Results.–The majority of migraineurs recalled no change in headaches with oral contraceptive use or hormone replacement therapy (67.2% and 77%, respectively). Worsening of migraines with oral contraceptive use was associated with a menstrual trigger, worsening during pregnancy, and a diagnosis of migraine without aura. Worsening with hormone replacement therapy was associated with worsening during prior oral contraceptive use, improvement during pregnancy, worsening during menopause, and a diagnosis of migraine without aura. Conclusions.–Prospective studies are needed to confirm these associations.