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Frequency of Factor V Leiden in Juvenile Migraine With Aura
Author(s) -
Soriani Stefano,
BorgnaPignatti Caterina,
Trabetti Elisabetta,
Casartelli Alessandro,
Montagna Pasquale,
Pignatti Pier Franco
Publication year - 1998
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1046/j.1526-4610.1998.3810779.x
Subject(s) - migraine , aura , migraine with aura , factor v leiden , medicine , risk factor , population , juvenile , mutation , familial hemiplegic migraine , pediatrics , gastroenterology , genetics , thrombosis , biology , environmental health , gene , venous thrombosis
Patients with migraine are known to be at risk for stroke. It has been reported that in a group of patients with cerebral ischemia and the Leiden mutation of factor V, 67% had classical migraine. We have studied the frequency of this mutation in a group of Italian children and adolescents affected by migraine with aura. The Leiden mutation was detected in 2 (3.5%) of 57 patients and in 8 (3.7%) of 219 controls. The 2 patients carrying the mutation had no peculiar characteristics as compared with the rest of the migrainous population. In our study, the frequency of the Leiden mutation in patients was not different from that of controls. These data contrast with those collected in the Finnish population and in a group of northwestern Italian adult patients, but agree with results previously reported from The Netherlands.