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Serotonergic, Catecholaminergic, and Cardiovascular Reactions to Mental Stress in Female Migraine Patients. A Controlled Study
Author(s) -
Stronks Dirk L.,
Tulen Joke H. M.,
Verheij René,
Boomsma Frans,
Fekkes Durk,
Pepplinkhuizen Lolke,
Mantel Geert W. H.,
Passchier Jan
Publication year - 1998
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1046/j.1526-4610.1998.3804270.x
Subject(s) - migraine , serotonergic , catecholaminergic , medicine , tension headache , mental stress , anesthesia , cardiology , serotonin , catecholamine , receptor
This study aimed at the combined assessment of the serotonergic and sympathetic nervous system reactions of migraine patients before, during, and after the induction of mental stress in order to detect the possible role of these reactions in inducing a migraine attack. The responses to mental stress of the migraine patients were compared to a group of patients suffering from tension headache and a control group. Activation of the sympathoadrenomedullary system due to mental stress was successfully induced in the migraine patients (n=23), in the tension headache patients (n=18), and in the control group (n=22). The results of this study present evidence of increased cardiovascular activity in migraine patients as compared to nonmigraineurs. However, no evidence was found of a specific serotonergic, sympathoadrenomedullary, or cerebrovascular response of migraine patients to mental stress as compared to nonmigraineurs.