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Derangement of Serotonin System in Migrainous Patients With Analgesic Abuse Headache: Clues From Platelets
Author(s) -
Srikiatkhachorn Anan,
Maneesri Supang,
Govitrapong Piyarat,
Kasantikul Vira
Publication year - 1998
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1046/j.1526-4610.1998.3801043.x
Subject(s) - platelet , analgesic , serotonin , migraine , vacuole , anesthesia , medicine , platelet activation , endocrinology , pharmacology , chemistry , receptor , biochemistry , cytoplasm
Accumulating evidence indicates that serotonin (5‐HT) may be involved in the process of analgesic‐induced headache transformation. In order to clarify this hypothesis, we investigated the 5‐HT system in migraine patients with analgesic abuse headache by using platelets as a neuronal model. Our results revealed a significant decrease in platelet 5‐HT content in these patients compared to migraine patients and nonheadache controls (179.24 ± 10.18, 451.22 ± 14.35, and 480.22 ± 13.98 ng/10 9 platelets, respectively; P <0.001). This biochemical result was well correlated with a significant decrease ( P