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Transdermal Clonidine in the Prophylaxis of Episodic Cluster Headache: An Open Study
Author(s) -
Leone Massimo,
Attanasio Angelo,
Grazzi Licia,
Libro Giuseppe,
D'Amico Domenico,
Moschiano Franca,
Bussone Gennaro
Publication year - 1997
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1046/j.1526-4610.1997.3709559.x
Subject(s) - clonidine , medicine , cluster headache , transdermal , anesthesia , transdermal patch , migraine , pharmacology
Transdermal clonidine has recently been reported to be efficacious in the prophylaxis of cluster headache. A 2‐week course of transdermal clonidine (5 mg the first week, 7.5 mg the second week) prceded by a 5‐day run‐in period, was administered to 16 patients with episodic cluster headache in an active cluster period. In 5 patients, the painful attacks. disappeared after the seventh day of treatment. For the group as a whole, no significant variations in headache frequency. pain intensity, or attack duration were observed between the run‐in period and the first and second weeks of treatment (ANOVA). Further studies are necessary to clarify the effectiveness of transdermal clonidine in the prophylaxis of episodic cluster headache.