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Lipid Composition of Platelets in Patients Suffering From Migraine Without Aura
Author(s) -
Vecino Ana M.,
AlvarezCermeño José C.,
JimenezHuete Adolfo,
Navarro José L.,
Cesar Jestis M.
Publication year - 1996
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1046/j.1526-4610.1996.3607440.x
Subject(s) - phosphatidylethanolamine , phospholipid , aura , phosphatidylserine , sphingomyelin , migraine , phosphatidylcholine , phosphatidylinositol , platelet , medicine , migraine with aura , endocrinology , chemistry , cholesterol , biochemistry , membrane , kinase
Patients with migraine have a platelet hyper‐aggregability. As this alteration could be the consequence of an abnormal lipid composition of platelet membranes, we studied the phospholipid specimens and the cholesterol/phospholipid ratio in platelets of seven patients suffering from migraine. The holesterol/phospholipid ratio was 0.7 ± 0.1 (normal 0.6 ± 0.1, molar ratio). The proportion of five main platelet phospholipids components including phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, phosphatidylserine, and phosphatidylinositol, were also normal. These data suggest that platelet hyperactivity in patients with migraine is not due to an altered lipid content of these cells.