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Low‐density Lipoprotein Apheresis in the Treatment of Peripheral Arterial Disease
Author(s) -
Kawashima Akira
Publication year - 2003
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1046/j.1526-0968.2003.00077.x
Subject(s) - medicine , apheresis , ldl apheresis , familial hypercholesterolemia , peripheral , lipoprotein , coronary artery disease , cardiology , low density lipoprotein , arterial disease , coagulation , disease , ldl receptor , vascular disease , platelet , cholesterol
Low‐density lipoprotein (LDL) apheresis is performed in patients with homozygous familial hyper‐cholesterolemia who lack LDL receptors and with heterozygous familial hypercholesterolemia who are LDL receptor deficient with documented, symptomatic coronary artery disease who are resistant to diet changes and maximum drug therapy. LDL apheresis can reduce or abolish anginal symptoms and improve coronary lesions. Several reports reveal the improvement of insufficient peripheral blood flow. By extensively removing blood LDL and changing coagulation factors and various vasoactive substances, LDL apheresis improves blood rheology and thereby peripheral circulation. It seems worth trying on all patients with arteriosclerotic lesions, even if they are normocholesterolemic.