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A Case Report of Total Abdominal Hysterectomy Resulting in Acute Thrombotic Thrombocytopenic Purpura with Pancreatitis and Hepatitis: Complete Resolution with Plasma Exchange Therapy
Author(s) -
Kathula Satheesh K.,
Koduri Jhansi,
Mall Sunita,
Chang Jae C.
Publication year - 2003
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1046/j.1526-0968.2003.00058.x
Subject(s) - medicine , thrombotic thrombocytopenic purpura , acute pancreatitis , schistocyte , microangiopathic hemolytic anemia , hemolytic anemia , pancreatitis , disseminated intravascular coagulation , surgery , gastroenterology , platelet
Acute thrombotic thrombocytopenic purpura (TTP) is a life‐threatening disorder that has previously been described associated with various types of surgery. An association between total abdominal hysterectomy (TAH) and TTP has never been reported. Thrombotic thrombocytopenic purpura is classically characterized by thrombocytopenia, microangiopathic hemolytic anemia, fever, azotemia and neurological manifestations. Atypical manifestations of TTP include hepatitis, pancreatitis, acute respiratory distress syndrome, non‐occlusive mesenteric ischemia and peripheral digital ischemia. This case report describes the occurrence of acute TTP following TAH and bilateral salpingo‐oopherectomy, which manifested with typical and atypical features (i.e. hepatitis, pancreatitis). Plasma exchange therapy resulted in the complete resolution of the process.