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Therapeutic Plasma Exchange in Patients with Grade 2–3 Hematopoietic Stem Cell Transplantation‐associated Thrombotic Thrombocytopenic Purpura: A Ten‐year Experience
Author(s) -
Christidou Fotini,
Athanasiadou Athanasia,
Kalogiannidis Panagiotis,
Natse Taïsir,
Bamichas Gerasimos,
Salum Riant,
Sakellari Ioanna,
Anagnostopoulos Achileas,
Fassas Athanasios,
Sombolos Kostas
Publication year - 2003
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1046/j.1526-0968.2003.00026.x
Subject(s) - medicine , thrombotic thrombocytopenic purpura , hematopoietic stem cell transplantation , transplantation , retrospective cohort study , therapeutic plasma exchange , gastroenterology , haematopoiesis , platelet , surgery , stem cell , biology , genetics
In the present retrospective study we report our 10‐year experience with therapeutic plasma exchange (TPE) in 18 patients with grade 2–3 hematopoietic stem cell transplantation (HSCT)‐associated thrombotic thrombocytopenic purpura (TTP). During TPE a mean total quantity of 26.5 ± 15.1 L of plasma was exchanged. Five patients (27.7%) had a complete response eight patients (44.4%) had a partial response while five patients (27.7%) died during TPE treatment. Among the survivors, relapse of TTP occured in three patients (23%) and although these patients were treated again with TPE, all died. First‐year survival rate was 41.2%. Our results indicate that TPE may be effective in the treatment of some patients with grade 2–3 HSCT‐associated TTP.