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Blood Purification Therapies Using Dextran Sulfate Cellulose Columns Liposorber and Selesorb
Author(s) -
Asahi Takashi,
Yamamoto Takashi,
Kutsuki Hidetoshi
Publication year - 2003
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1046/j.1526-0968.2003.00018.x
Subject(s) - medicine , dextran , antibody , cellulose , chromatography , ligand (biochemistry) , carboxymethyl cellulose , pharmacology , immunology , biochemistry , receptor , sodium , organic chemistry , chemistry
Liposorber is a column used for plasma purification that adsorbs low‐density lipoproteins with high selectivity, while Selesorb is a column that selectively adsorbs anti‐DNA antibodies, anticardiolipin antibodies, and immune complexes. Both columns are packed with carriers, where a dextran sulfate ligand is bound to porous cellulose beads. Liposorber is used to treat familial hypercholesterolemia (FH), peripheral arterial disease (PAD), and focal segmental glomerulosclerosis (FGS): Selesorb is used to treat systemic lupus erythematosus (SLE). Treatment utilizing both columns is being used effectively in patients with refractory disease that is resistant to pharmacotherapy.