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Decreased 2,3‐Diphosphoglycerate Concentration in Low Cardiac Output Patients and Its Influence on the Determination of In Vivo P 50
Author(s) -
Piccioni Marilde A.,
Cestari Idágene A.,
Strunz Célia M.C.,
Auler José O.
Publication year - 2003
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2003.07272.x
Subject(s) - in vivo , diphosphoglycerate , cardiac output , cardiopulmonary bypass , cardiology , chemistry , medicine , anesthesia , hemodynamics , hemoglobin , biology , microbiology and biotechnology
We investigated whether 2,3‐diphosphoglycerate (2,3‐DPG) is altered in patients with low cardiac output and the influence of its concentration on the calculation of in vivo P 50 . Biochemical and blood gas analysis were performed along with the measurement of cardiac output and body temperature in 13 patients submitted to cardiopulmonary bypass surgeries without the use of donor blood. In vivo P 50 was calculated using the measured (P 50m ) and the estimated 2,3‐DPG (P 50e ). 2,3‐DPG concentration was lower in these patients when compared to the values obtained in normal volunteers (6.9 ± 2.2 vs. 11.9 ± 2.4 μmol/gHb). P 50m was lower than P 50e (21.6 ± 1.1 vs. 30.1 ± 1.2 mm Hg) at all time points. Our data show that in patients with low cardiac output, 2,3‐DPG concentration is reduced. Therefore, in these patients, the use of standard values for this variable may introduce an error in the calculation of in vivo P 50 .