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The Effect of Vitamin E–Bonded Dialyzer Membrane on Red Blood Cell Survival in Hemodialyzed Patients
Author(s) -
Nakatan Tatsuya,
Takemoto Yoshiaki,
Tsuchida And Kenji
Publication year - 2003
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2003.07214.x
Subject(s) - red blood cell , hemodialysis , vitamin e , anemia , life span , oxidative stress , creatine , membrane , red cell , erythrocyte membrane , chemistry , medicine , endocrinology , biochemistry , antioxidant , gerontology
Reduced red blood cell (RBC) survival due to oxidative damage is one of the causes of anemia in patients under long‐term hemodialysis. Recently, it has been shown that vitamin E–bonded dialyzer membrane is able to reduce the oxidative stress during hemodialysis. In humans, creatine content in RBC is used to measure RBC life span and erythropoietic capacity, since it rapidly declines as the RBCs become old. Therefore this study aimed to elucidate the effect of vitamin E–bonded dialyzer membrane on RBC life span by measuring creatine content in RBC.