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Porcine Stentless Bioprostheses: Prevention of Aortic Wall Calcification by Dye‐Mediated Photo‐Oxidation
Author(s) -
Meuris Bart,
Phillips R.,
Moore Mark A.,
Flameng Willem
Publication year - 2003
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2003.07108.x
Subject(s) - calcification , medicine , cardiology
Purpose : Aortic wall calcification is problematic in stentless porcine valves. We evaluated the possible anticalcification effect of photo‐oxidation on the aortic wall portion of porcine stentless bioprostheses. A comparison with glutaraldehyde‐fixed tissue was made. Methods : Six Photofix and six Freestyle valves were implanted in juvenile sheep in pulmonary position. Valves were explanted after 3 or 6 months and examined macroscopically, by x‐ray, light, and transmission electron microscopy. Calcium content was determined by atomic absorption spectrometry. Results : The aortic wall portion of all Photofix valves remained free from calcification, while the wall portion of glutaraldehyde‐fixed valves calcified strongly, both after 3 and 6 months. Calcium content of the aortic wall portion was: 0.71 ± 1.27 in the Photofix valves versus 10.78 ± 77.22 in the Freestyle valves ( P < 0.05). Conclusion : Photo‐oxidation of a porcine stentless valve prevents calcification not only in the cusps but also in the aortic wall portion.