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Chronic Evaluation of the Cleveland Clinic CorAide Left Ventricular Assist System in Calves
Author(s) -
Fukamachi Kiyotaka,
Ochiai Yoshie,
Doi Kazuyoshi,
Massiello Alex L.,
Medvedev Alexander L.,
Horvath David J.,
Gerhart Renee L.,
Chen JiFeng,
Krogulecki Alexandra Y.,
Takagaki Masami,
Howard Michael W.,
Kopcak Michael W.,
Golding Leonard A.R.
Publication year - 2002
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2002.06994.x
Subject(s) - medicine , centrifugal pump , thrombus , hemodynamics , artificial heart , biocompatibility , ventricular assist device , blood flow , hemolysis , peristaltic pump , stenosis , cardiology , heart failure , surgery , impeller , materials science , meteorology , metallurgy , physics , thermodynamics
The Cleveland Clinic CorAide left ventricular assist system is based on a third‐generation, implantable, centrifugal pump in which a rotating assembly is suspended fully. To evaluate chronic in vivo system performance and biocompatibility, the CorAide blood pump was implanted in 18 calves for either 1 month or 3 months. Hemodynamics were stable in all calves with a mean pump flow of 5.9 ± 1.2 L/min and a mean systemic arterial pressure of 98 ± 5 mm Hg. There were no incidences of bleeding, organ dysfunction, or mechanical failure in any of the 18 calves. Hemolysis occurred in only 1 calf due to outflow graft stenosis. Thrombus inside the pump, seen in 4 of the first 6 cases, was totally eliminated by a final redesign in the remaining cases, including the last 6 implants conducted without anticoagulation therapy. The CorAide blood pump demonstrated good biocompatibility and reliable, effective system performance.