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Nonnstimulated Cardiomyoplasty Improves Hemodynamics in Myocardial‐Infarcted Rats
Author(s) -
De Angelis Kátia,
Leirner Adolfo A.,
Irigoyen Maria Cláudia,
Cestari Idágene A.
Publication year - 2001
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2001.06907.x
Subject(s) - cardiology , cardiomyoplasty , medicine , myocardial infarction , hemodynamics , diastole , heart failure , blood pressure , cardiac function curve , ventricular pressure , artery
Cardiomyoplasty has been proposed as an alternative surgical treatment for congestive heart failure. The girdling effect of the muscle wrap is believed to reduce diastolic wall stress. We tested the hypothesis that nonstimulated or passive cardiomyoplasty (CDM) would reduce hemodynamic deficits in rats with experimentally induced myocardial infarction (MI). Four groups of animals were studied: intact (C, n = 6), CDM (n = 6), MI by ligation of the left coronary artery (n = 6), and left latissimus dorsi CDM performed 14 days post‐MI (MI + CDM, n = 6). All groups were studied 8 weeks after MI and/or CDM or from the beginning of the experiment in controls. MI rats had a lower mean arterial pressure and higher end‐diastolic pressure (EDP) compared with controls. End‐diastolic pressure (EDP) and the left ventricular‐body weight ratio (LV/BW) were reduced in the MI group after CDM. These data suggest that passive girdling of the heart provided by CDM may improve post‐MI cardiac function.