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Antiinflammatory Effect of Heparin‐Coated Circuits with Leukocyte‐Depleting Filters in Coronary Bypass Surgery
Author(s) -
Hamada Yoshihiro,
Kawachi Kanji,
Nakata Tatsuhiro,
Kohtani Takashi,
Takano Shinji,
Tsunooka Nobuo
Publication year - 2001
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2001.06754.x
Subject(s) - cardiopulmonary bypass , heparin , medicine , arterial line , anesthesia , inflammatory response , cardiology , inflammation
Cardiac surgery with cardiopulmonary bypass is associated with a systemic inflammatory response. We examined combined use of heparin coating of the cardiopulmonary bypass circuit and a leukocyte‐depleting arterial line filter to reduce this response. Thirty patients were allocated randomly to equal groups with a conventional circuit and arterial line filter (C group), a heparin‐coated circuit with a conventional filter (H group), or a heparin‐coated circuit with a leukocyte‐depleting arterial line filter (HF group). Cytokines and respiratory function were repeatedly measured perioperatively. Plasma interleukin (IL)‐6 concentrations in the HF group were lower than in the C group immediately following bypass and operation, at 4 h, and 12 h (p < 0.05). Plasma IL‐8 was lower in the HF group than in the C group at 4 h (p < 0.05). The respiratory index was lower immediately after bypass in the HF group than the C group (0.61 ± 0.2 versus 1.05 ± 0.4, p < 0.05). Heparin‐coated circuits with leukocyte‐depleting filters decrease inflammatory responses and improve pulmonary function during operation.