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Gas Transfer Performance of a Hollow Fiber Silicone Membrane Oxygenator: Ex Vivo Study
Author(s) -
Kawahito Shinji,
Maeda Tomohiro,
Takano Tamaki,
aka Kenji,
Linneweber Joerg,
Mikami Minoru,
Motomura Tadashi,
Ichikawa Seiji,
Glueck Julie,
Sato Koshiro,
Kuwana Jiro,
Nosé Yukihiko
Publication year - 2001
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2001.06706-4.x
Subject(s) - membrane oxygenator , oxygenator , extracorporeal membrane oxygenation , ex vivo , hollow fiber membrane , cardiopulmonary bypass , fiber , medicine , silicone , biomedical engineering , membrane , materials science , volumetric flow rate , anesthesia , in vivo , chemistry , composite material , biochemistry , physics , microbiology and biotechnology , quantum mechanics , biology
Based on the results of in vitro studies of many experimental models, a silicone hollow fiber membrane oxygenator for pediatric cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) was developed using an ultrathin silicone hollow fiber with a 300 μm outer diameter and a wall thickness of 50 μm. In this study, we evaluated the gas transfer performance of this oxygenator simulating pediatric CPB and ECMO conditions. Two ex vivo studies in a pediatric CPB condition for 6 h and 5 ex vivo studies in an ECMO condition for 1 week were performed with venoarterial bypass using healthy calves. At a blood flow rate of 2 L/min and V/Q = 4 (V = gas flow rate, Q = blood flow rate) (pediatric CPB condition), the O 2 and CO 2 gas transfer rates were maintained at 97.44 ± 8.88 (mean ± SD) and 43.59 ± 15.75 ml/min/m 2 , respectively. At a blood flow rate of 1 L/min and V/Q = 4 (ECMO condition), the O 2 and CO 2 gas transfer rates were maintained at 56.15 ± 8.49 and 42.47 ± 9.22 ml/min/m 2 , respectively. These data suggest that this preclinical silicone membrane hollow fiber oxygenator may be acceptable for both pediatric CPB and long‐term ECMO use.