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Change in Vasoconstrictive Function During Prolonged Nonpulsatile Left Heart Bypass
Author(s) -
Nishinaka Tomohiro,
Tatsumi Eisuke,
Nishimura Takashi,
Shioya Kyoko,
Ohnishi Hiroyuki,
Taenaka Yoshiyuki,
Takano Hisateru
Publication year - 2001
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2001.025005371.x
Subject(s) - phenylephrine , medicine , cardiology , pulsatile flow , vascular resistance , anesthesia , hemodynamics , blood pressure
We investigated changes in vasoconstrictive function accompanying prolonged nonpulsatile left heart bypass (NLHB). After 2‐week pulsatile left heart bypass (PLHB) in 11 goats, NLHB was conducted for another 4 weeks (Group N) in 6 goats. In the other 5 goats, PLHB was continued for another 4 weeks (Group P). Systemic vascular resistance at rest (rSVR) was measured on the last days of the second and sixth postoperative week (W2 and W6, respectively). Subsequently, phenylephrine was injected, and the maximum values (SVR max ) and the maximum increasing change in SVR (ΔSVR) were measured. No significant difference was observed in rSVR between groups at W2 or W6. The SVR max and the ΔSVR at W2 were consistent in both groups. However, at W6, the SVR max and the ΔSVR of Group N were significantly lower than those of Group P. In conclusion, prolonged NLHB caused a significant decrease in the SVR response to phenylephrine, indicating a dimunition of vasoconstrictive function.