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Cerebral Tissue Oxygen Saturation During Percutaneous Cardiopulmonary Support in a Canine Model of Respiratory Failure
Author(s) -
Wada Hideichi,
Watari Masanobu,
Sueda Taijiro,
Kochi Kazuhiro,
Sakai Hiroshi,
Shibamura Hidenori,
Imai Katsuhiko,
Fukunaga Shintaro,
Orihashi Kazumasa,
Matsuura Yuichiro
Publication year - 2000
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2000.06601.x
Subject(s) - medicine , cardiopulmonary resuscitation , respiratory failure , heart failure , oxygen saturation , respiratory system , cardiology , anesthesia , oxygen , resuscitation , chemistry , organic chemistry
Percutaneous cardiopulmonary support (PCPS) has come to be applied for cardiopulmonary resuscitation and in the management of severe respiratory failure as well as severe heart failure. We investigated cerebral tissue oxygen saturation during PCPS in a canine model of respiratory failure using near‐infrared spectroscopy. Animals were mechanically ventilated with 10% oxygen to make a respiratory failure model. Perfusion with PCPS was performed via the left femoral artery and switched to that via the right axillary artery. Cerebral tissue oxygen saturation was 54.2 ± 3.4% during PCPS via the femoral artery and was 82.3 ± 4.6% during PCPS via the axillary artery (p = 0.001). Hepatic tissue oxygen saturation was not significantly different. LV dP/dt max increased significantly after switching to the axillary blood supply (p = 0.001). Conventional PCPS may not have the capability of supporting cerebral circulation under severe respiratory failure without organic heart disease.