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Clinical Evaluation of Heparin‐Coated Circuits for Routine Coronary Artery Bypass Grafting Surgery: A Prospective Randomized Study
Author(s) -
Collart Frédéric,
Caus Thierry,
Pomane Claude,
Pellissier Véronique,
Chi Yfan,
Montiès JeanRaoul,
Mesana Thierry
Publication year - 2000
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2000.06599.x
Subject(s) - medicine , heparin , bypass grafting , hemostasis , artery , surgery , randomized controlled trial , prospective cohort study , anesthesia
Abstract: The aim of this study was to demonstrate the clinical and biological benefits of heparin‐coated circuits in routine coronary artery bypass grafting (CABG). A prospective, randomized study was conducted in 80 patients undergoing routine CABG. Patients were randomized to either noncoated circuits (Group 1) or heparin‐coated circuits (Group 2). A complete clinical evaluation was performed preoperatively at Days 0, 1, 2, and 3 and at discharge day and combined with extensive laboratory tests for hemostasis and inflammatory response. This study did not prove any major statistically significant clinical benefit of heparin‐coated circuits in low risk patients. Postoperative bleeding, significantly less in the heparin‐coated group, did not decrease significantly the number of transfused patients. Biological values were not changed significantly except for factor II and monocytes, which were higher in Group 2. Heparin‐coated circuits offer minimal clinical and biological benefits for routine CABG surgery. However, they may prove beneficial for complex procedures or at‐risk patients.